Standard military configuration is 2-piece rims + the beadlock/runflat insert, most military HMMWVs do not have CTIS.
Personally I don't want the weight and balance issues of the runflat (and I don't offroad where I'm expecting to have problems that would need a runflat), so I just use a PVC beadlock insert instead.
But I don't see any reason why you couldn't run CTIS or no-CTIS w/ any combination. Just keep in mind with the two piece military rims, the angle of the bead is a bit different then a 'normal' civilian rim.. so IMHO an inner beadlock is recommended so you don't lose the tire if you do run air pressure too low (or get a flat).