If you want to get stuff out of the tank and lines, then yes. You can also run biocide if its been sitting for a while.
If you want to purge the pump, injectors, etc and clean them out, then you disconnect the supply line going to the IP/PT pump, and your mix of seafoam, power service, ATF/OIL mixed into a gallon jug and have the engine suck it all in directly instead of pulling from the tank.
That's one of the great things about older diesels like the NHC250, and to some extent the 6cta8.3.... looser tolerances mean it's not as picky about fuel... Do NOT let it run out of fuel though.. It uses fuel as lube for the pump.
I literally ordered a gallon of MMO, a gallon of TCW3 (2 stroke oil), 2 cans of seafoam, 2 cans of wallyworld version of seafoam, and a gallon of ATF, because this convo reminded me I needed to do it to my new truck.... I plan on doing a pump/injector purge which means I'm gonna take half of the above, dump it in a pail, and suck it directly in, and the remainder will be dumped into the fuel tank and diluted. By sucking it in directly, it's not diluted with fuel.
I couldn't get powerservice diesel kleen, otherwise I would have added that to my list...
The seafoam will provide the immediate cleaning ability, the ATF has detergents, the TCW3 and MMO provides lubricity. All of which are readily combustible in a diesel engine with no issues.
You really don't need to do a purge that often, but my truck is 30 years old and I guarantee it's never been done.
TCW3 is something I suggest in every tank...1 oz per gallon, but more won't hurt. the ULSD of today doesn't have the lubricity that older diesel does... which the engine was designed to run on..
It's actually very common to dump seafoam 100% strength into diesel fuel filters when changing them.... to clean things out... This is just a longer, more complex version, on steroids.... when purging....
By diluting it with fuel in your tank you have a gentler effect over a longer time, as the chemicals work in the tank/line.
That's why I do both. Half to do a quick deep clean of the injectors/pump, the other half to continue cleaning the rest of the system, for the remainder of the tank.
You will notice a quieter running engine on the TCW3 alone..
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