Make sure tires are full to rated pressure. Beyond that, yes, the RV users of the 8.3L see large fuel economy gains by advancing injection timing (they bump up from 12 to 16 degrees, we are at 8 stock), and they also lay smaller yet positive claim to economy gains with a straight through muffler such as the Aeroturbine 4040XL (now mfg by Jones). Both yes as you say. Not sure it has ever been quantified here, but can’t imagine it to be much different.