These are predominantly intended for use as off road tires. They leak a lot. If they leak down far enough, the runflats take over and will damage the tire. You might not know this without inspecting from the inside. That's why you see about a million tons of them at GL in the scrapyards. The problem is, the seals on the two piece rims. The tires should be taken apart and inspected if you want to max them out on speed or pressure. High speed seems to be as much an issue as heavy loads. Civilians use them at higher speeds then the military.
The tech manual offers this as preventive maintenance.
"O-ring sealing surfaces and pressure relief grooves must be kept clean and free of rust and dirt. Failure to
do so could cause the wheel assembly to separate under pressure, causing serious injury or death."
Oops, I didn't copy it all, sorry. There is more on proper maintenance, care, and warnings of these tires in the tech manual, including inspection of the sidewalls and damage as a result of running the runflats, as well as a number of articles on them and hazards of leaks being established when using the high end of 50psi. We just don't really know all the issues of these withtout breaking them completely down and inspecting so I would not recommend running up the cold air pressure to the max, knowing at high speed they will rise even further, and put drivers and passenger at risk with the unknown issues. That's why I would say, don't do it.
No one needs 50 psi in these tires on a M1101/1102 trailer with the comparatively light load vs a HMMWV loaded. 35-40 is fine.