You'll spend some time and cash getting one up to snuff, but at the end of the day it's a CAT engine with an Alison transmission.
Operating expenses scale, so not knowing what trucks you normally run it's hard to compare. It's closer to maintaining a semi. Bigger tools, bigger volumes, bigger tires to replace.
Great trucks, but you have to get it to a certain stage to be "dependable". Replacing all the rubber, going thru all the electrical grounds, fluids, filters, batteries, balancing the drive shafts, replacing tires, a few minor mods...all things that add up. And you'll likely want to do the ECO Hub mod to reduce the wear and tear (cut the engine and drive train speeds in half), improve mileage, and increase you top speed as a result.
But it's easy to toss another $10K on top of the price to get a truck up to speed (and that's with you doing the labor).