Tires are 1 1/2 lug wrench right?
The super single tire and rim weighs about 500 pounds and you have to know how to disassemble the CTIS to get the tire off.
Many of the parts are made of pot metal and will break in a heartbeat if that heavy assembly hits them wrong.
If you have a catastrophic tire failure, very common if the tires have sat flat, you would be better off to call a service truck and tell them what you have.
I have changed them in the yard (when swapping out an axle) but I have a one inch impact wrench and a tractor to move the tires around with.
If the Basis Issue Items (BII) are not with the truck getting the spare off the holder will be an interesting exercise. If you don't have the chain fall and related equipment to use the tire davit you will have to let gravity do the work and stopping a 500 pound tire after the four foot drop off the holder is the stuff "America's Funniest Videos" are made of.
Again the TM should have the instructions on how to change a tire. Print it out and have it with you.