In my opinion the tr6060 is a very poor choice for an off road/truck transmission. If you just want to cruise the highway however that is what the 6060 was designed for and it could be a good option.
With only 3.0 reduction in first gear compared to 5.5-6.5 reduction in an SM465 or NV4500, the overdrive doesn't really help you that much. When off road or towing, a tr6060 in 1st with 4.56 gears will have the same total reduction as an SM465 in 1st with about 2.08 gears, if that was even possible. (2.97 x 4.56 = 13.54, while 6.55 x 2.08 = 13.62)
What you're looking for in an off road/towing trans isn't the deepest overdrive, but the largest gear spread between the bottom and top ratio. In the tr6060 that is 2.97 / 0.63 = 4.71, in a SM465 it's 6.55 / 1.0 = 6.55. If you're willing to give up all the low gearing that comes with a truck/4x4 transmission, you might as well just run a cheap SM465 with really tall axle gears to get your highway speed instead. You'll get better mileage that way too, because the lower reduction hypoid gears in the rear axle will have less loss compared to a higher ratio and a 1:1 ratio in the main transmission will be more mechanically efficient than another gear stage (overdrive).