I have done that trip and then some. Just take it easy. The worst part will be the Appalachian mountain chain. My clutch started slipping some there but then again, I was probably in a slightly overloaded condition.
I normally carry tools, 5 gallons fuel (use to carry more but I've become pretty good at timing my stops), 3 gallons oil, 3 gallons 50/50, 5 gallon can of water in the back, fire extinguisher, tire changing stuff, spare wheel bearing, reflective vest, good flashlight, triangle kit, magnetic clock/timer, grease pencil don't forget the large empty Gatorade bottle. I have an M35A3 seat in my truck and that's a big difference over the standard seats.
My boredom is somewhat alleviated by calculating time/distance/arrival times/fuel estimates and other such nuances hence the magnetic clock/timer. I mark mile markers for each state along the route on the windshield in grease pencil. You can get this off the web. For example, I recall South Carolina is 104 miles on I-85. I would hit the tanker south bound just after crossing the line. From that point is was 2 hours to get to the GA line depending on weather and traffic. I would always time my route to his populated areas during off peak traffic times. Very high populated areas (like Dallas or Atlanta) would be calculated to go through very early in the morning. I would pull off at truck stops/rest stops and sleep to hit those city checkpoints on a rough schedule. Last time I overslept before going through San Antonio and was hating life before I got through there.
Two years ago I did 1502 miles in just under 48 hours in my loaded deuce with loaded M1061 trailer coming out here and I probably could have shaved off a little more. Bottom line is, it is do-able just make sure you do a good PMCS before departing. My record was 2200 miles in a loaded deuce with loaded M1061 trailer in 4 days but that also included going out of my way to get two loads (so it was over 2200 miles actually).
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